LCSSs are available for PubChem Compound records that have hazard classification information based on the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) 10. This paper also describes ongoing community efforts to apply the LCSS to build chemical safety information systems at academic institutions. This conference paper describes PubChem’s LCSS data view, including compound coverage, data contents, web accessibility, and download-ability. Records are cross-mapped between the three databases as described in more detail elsewhere. The BioAssay database ( ) archives descriptions and results of biological assay experiments.
The Compound database ( ) contains unique chemical structures extracted from the Substance database. The Substance database ( ) stores chemical substance descriptions submitted by individual data contributors. PubChem consists of three primary databases: Substance, Compound, and BioAssay. PubChem is a chemical information resource developed and maintained by the U.S. A partial screenshot of the Laboratory Chemical Safety Summary (LCSS) page for tetrahydrofuran (CID 8028) ( ). This format is intended to supplement the more traditional MSDS by providing a concise view of data types most relevant to use of chemicals as described in the OSHA lab standard. In order to support this risk assessment process by providing researchers, educators and students with electronic access to chemical health and safety information, PubChem 4-8 ( ) provides a “Laboratory Chemical Safety Summary” (LCSS) data view ( Figure 1) for thousands of chemicals ( ). 3 Many different chemicals are used in laboratory work and these risk assessments require ready access to safety information for a large number of chemicals. Approaches to laboratory chemical risk assessment have been suggested by the American Chemical Society’s Committee on Chemical Safety.
These accidents are described in two reports from the US Chemical Safety Board 1,2 addressing chemical safety in education settings and research labs.
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If desired, LCSS data can be downloaded from the LCSS page for each compound, or in bulk from the PubChem LCSS project webpage.Ī series of high profile laboratory accidents over the last seven years has increased the academic community’s awareness of the importance of chemical risk assessment in laboratories, both teaching and research. In addition, one can get the complete list of chemicals with an LCSS by visiting the PubChem LCSS project webpage ( ) or by using the PubChem Classification Browser ( ). If a PubChem Compound record has an LCSS, the link to view it is provided at the top of the Compound Summary page of that compound under the heading “Safety Summary”. PubChem is actively recruiting this GHS information from additional contributors in order to expand its LCSS coverage. LCSSs are available for PubChem Compound records which have GHS (Globally Harmonized System of Classification and Labeling of Chemicals) hazard classification information from PubChem’s data contributors. This information often extends beyond that found on Safety Data Sheets for the chemical of interest. Of special interest in this collection is specific “Stability and Reactivity” information, which lists known chemical reactions between the chemical of interest and other chemicals and chemical classes. National Institute for Occupational Safety and Health (NIOSH), the Occupational Safety and Health Administration (OSHA), and the International Labor Organization (ILO). These data are provided by various data contributors, including authoritative agencies such as the U.S. Information contained in the LCSS is a subset of the PubChem Compound Summary page content, and includes information on flammability, toxicity, exposure limits, exposure symptoms, first aid, handling, clean up and more. The LCSS contains pertinent chemical health and safety data for a given PubChem Compound record, based on the format described by the National Research Council in “ Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards”.
In order to provide researchers, educators and students with electronic access to chemical health and safety information, PubChem provides a “Laboratory Chemical Safety Summary” (LCSS) data view for more than three thousand chemicals commonly encountered in laboratories ( ). Because of the many different chemicals used in laboratory work, these risk assessments require ready access to safety information for a large number of chemicals. A series of high profile laboratory accidents over the last 7 years has increased the academic community’s awareness of the importance of risk assessment in laboratories, both teaching and research.
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